Office: Hoyt 208
Office Phone: (402) 872-2269
Mon & Wed: 11:30-1:00
Tues & Thurs: 11:00-1:00
13 Fall Course Offerings:
Biol 102 (sections 000A, 000B & 000C ) - Introductory Zoology & Lab
Chem 101 (sections 000D, 000E & 000F) - General Chemistry, Lab & Recitation
14 Spring Course Offerings:
Biol 102 (sections 000C & 000D) - Introductory Zoology & Lab
Biol 130 (sections 000A & 000B) - General Biology & Lab
Biol 315 (section 000A) - Introductory Immunology
Dr. Gul Ahmad, is Assistant Professor of Biology at Peru State College since August 2012. Dr. Ahmad is a parasitologist by training with special interest in molecular parasitology and control of parasitic diseases. He has more than 20 years of research and teaching experience in some of the top academic Institutions of Old and New World. Dr. Ahmad completed his BS, MS, M. Phil and PhD. from Aligarh University, India. Upon completion of his doctoral degree in 1999, Dr. Ahmad was awarded the prestigious post doctoral fellowship by the Italy based International Center for Genetic Engineering and Biotechnology to work at their New Delhi Component on the molecular biology and protein chemistry of Plasmodium species. Dr. Ahmad worked in this United Nations sponsored Organizations until he was hired by School of Materials Sciences and Engineering, Georgia Institute of Technology, Atlanta, Georgia in June 2004. At Georgia Institute of Technology Dr. Ahmad was using his biochemistry and molecular biology skills to develop photonic and phononic materials in addition to the use of phage display technology in the development of peptide based nano-particles. In May 2007, Dr. Ahmad was recruited by the Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock Texas as a Research Assistant Professor. In 2011 Dr. Ahmad was awarded the unsung hero award by the Dean School of Medicine, Texas Tech University Health Sciences Center, Lubbock Texas, for his contribution in the development of schistosomiasis vaccine. Dr. Ahmad has published over 30 peer-reviewed journal articles which are cited more than 600 times with an h- index of 13.
Present Research Interest: Development of vaccines and other prevention methods for the control of parasitic diseases. My approach is to combine the emerging field of nanotechnology with that of molecular biology and immunology in order to confront the problem of parasitic diseases. Trichomonas vaginalis is a flagellated parasitic protozoan that infects the human uronogenital tract. It is estimated, that there are about 250 million new cases of trichomoniasis around the world. Some estimates indicate that 9 million new cases occur in the United States every year. RNA interference mediated by SiRNA is a promising approach for prevention and treatment of human diseases and is moving rapidly from basic science to clinical, applications. T. vaginalis has many proteinases which are mainly of cystein type. In vivo, trichmonal cysteine proteinases have been found in the vaginal secretions of patients with active trichomoniasis and some of them are immunogenic. T. vaginalis cysteine proteases have been related to nutrient uptake, immune evasion and virulence properties including cytoadherence. One aspects of my research interest is to investigate the effect of SiRNA specific for protease genes of Trichomonas vaginalis. Using the cutting edge techniquies of nanotechnology as a delivery method for silencing the protease gene (s) of this pathogen via a control release process of SiRNA, we intend to encapsulate SiRNA in FDA approved nanoparticles and test the efficacy of the small interfering RNA loaded in biodegradable nanoparticles in vitro and rodent model of trichomoniasis in vivo. Another aspect of my research is to test and find out new biodegradable nanoparticles which should be noninvasive as the agent and delivery systems must be effective, safe and non-irritating to the delicate vaginal mucosa in order to be useful as topical microbicide. Fortunately, I have hands on experience both from parasitological perspective as well as nanoparticles preparation and synthesis point of view. In addition to this I intend to use my hands on experience of developing, testing and evaluation of vaccines for schistosomiasis as a start point in order to develop and test a vaccine for trichomoniasis.
- Saifullah, M.K., Ahmad, G., Abidi, S.M.A.(2012) Immunodetction of coproantigens for the diagnosis of amphistomosis in naturally infected Indian Water Bufalo, Bubalus bubalis. Veterinary Parasitology (in press).
- Torben,W, Ahmad, G. Zhang,W, Nash, S., Le, L., Karmakar, S, & Siddiqui, A.A (2012). Roleof antibody dependent cell mediated cytotoxicity (ADCC)in Sm-p80-mediated protection against Schistosoma mansoni. Vaccine (in press).
- Ahmad, G., Zhang, W., Torben, W., Ahrorov, A., Damian RT., Wolf RF, White GL, Carey, DW, Mwinzi, PNM, Leal, LG, Kennedy RC & Siddiqui AA. (2011). Preclinical prophylactic efficacy testing of Sm-p80 based vaccine in nonhuman primate model of Schistosoma mansoni and IgG/IgE response to Sm-p80 in human sera from Schistosome endemic area. The Journal of Infectious Diseases. 204(9):1437-1449
- Saifullah, M.K., Ahmad, G., Abidi, S.M.A.(2011) Partial purification and charac-terization of Excretory/Secretory antigens of Gastrothylax crumenifer Veterinary Parasitology 180:232:236..PMID:21459515
- Torben,W, Ahmad, G. Zhang,W & Siddiqui, A.A (2011). Role of antibodies in Sm-p80-mediated protection against Schistosoma mansoni challenge infection in murine and nonhuman primate models. Vaccine 29:2262-2271. PMID: 21277404
- Zhang, W, Ahmad, G. Torben,W ,. & Siddiqui, A.A (2011). Schistosoma mansoni antigen Sm-p80: Prophylactic efficacy of a vaccine formulated in human approved plasmid vector and adjuvant (VR1020 and alum) Acta Tropica 118:142-151. PMID:21334302
- Ahmad, G. Zhang, W, Torben,W , Noor, Z. & Siddiqui, A.A (2010). Protective effects of Sm-p80 in the presence of resiquimod as an adjuvant against challenge infection with Schistosoma mansoni in mice. International Journal of Infectious Diseases 14:e781-e787. PMID: 20630783
- Zhang, W, Ahmad, G., Torben, W & Siddiqui, A.A (2010). Sm-p80- based DNA vaccine made in a human use approved vector VR1020 protects against challenge infection with Schistosoma mansoni in mouse. Parasite Immunology 32: 252-258. PMID: 20398225
- Ahmad, G., Zhang, W., Torben, W., Noor, Z., Le L., Damian RT., Wolf RF, White GL, Chavez-Suarez M, Podesta, RB, Kennedy RC & Siddiqui A.A. (2010).Sm-p80 based DNA vaccine protects baboons against Schistosoma mansoni infection to comparable levels achieved by irradiated cercarial vaccine. The Journal of Infectious Diseases 201: 1105-1112. PMID: 20187746
- Ahmad, G., Zhang, W., Torben, W., Haskins, C., Diggs, S., Noor, Z., Le, L & Siddiqui A.A. (2009). Prime-boost and recombinant protein vaccination strategies using Sm-p80 protects against Schistosoma mansoni infection in the mouse model to levels previously attainable only by irradiated cercarial vaccine Parasitology Research 105:1767-1777. PMID: 19809833
- Ahmad, G., Zhang, W., Torben, W., Damian RT., Wolf RF, White GL, Chavez-Suarez M., Kennedy RC & Siddiqui A.A. (2009). Protective and antifecundity effects of Sm-p80 based DNA vaccine formulation against Schistosoma mansoni in a nonhuman primate model, Vaccine 27: 2830-2837. PMID:19366570
- Ahmad, G., Torben, W., Zhang, W., Wyatt M., & Siddiqui A.A. (2009).Sm-p80 based DNA vaccine formulation induces potent protective immunity against Schistosoma mansoni. Parasite Immunology 31:156-161.PMID:19222788
- Siddiqui, A.A., Ahmad G., Damian RT & Kennedy RC. (2008). Experimental Vaccines in Animal Models for Schistosomiasis. Parasitology Research 102:825-833.PMID: 1825977.
- Ahmad, G., Dickerson, MB.,Ye Cai, Jones SE., Ernst, EM., Vernon,P.J Haluskaa,MS., Fang, Y.,Wang, J., Subramanyam, G. Naik, RR. & Sandhage K H. (2008) Rapid Bio-Enabled Formation of Ferroelectric BaTiO3 at Room Temperature from an Aqueous Salt Solution at Near Neutral pH. Journal of American Chemical Society 130: (1) 4-5.PMID:18067293
- Dickerson, M.B., Jones, S.E, Cai, Ye, Ahmad, G.,., Naik, R.R., Kröger, N.& Sandhage, K.H (2008). Identification and design of peptides for the rapid high yield formation of nanoparticulate TiO2 from aqueous solutions at room temperature. Chemistry of Materials 20 (4) 1578-1584
- Bao, Z., Weatherspoon, M.R., Shian, S., Cia Ye, Graham, P.D., Allan, S.M., Ahmad, G., Dickerson, M.B., Church, B.C., Kang, Z., Abernathy, H.W.III, Summers, C.J., Meilin, L. & Sandhage, K.H. (2007).Chemical reduction of three-dimensional silica micro-assemblies into microporous silicon replicas Nature, 446 (7132) 172-175.PMID: 17344850.
- Kusari, U., Bao, Z. , Cai, Y. Ahmad, G., Sandhage, K. H & Sneddon L. G.(2007) Formation of Nanostructured, Nanocrystalline Boron Nitride Microparticles with Diatom-Derived 3-D Shapes. Chemical Communication (11), 1177-1179 PMID: 17347731
- Kusari, U., Bao, Z. , Cai, Y. Ahmad, G., Sandhage, K. H & Sneddon L. G.(2006). Template routes to non-oxide ceramic nano-and microstructures. Material Research Society Symposium Proceedings, Volume: 921: 72-77.
- Kröger, N., Dickerson, M.B, Ahmad, G., Cia, Y., Haluska, M.S., Sandhage, K.H., Poulsen, N. & Sheppard, V.C. (2006). Bioenabled synthesis of rutile (TiO2) under mild reaction condition Angewandte Chemie International Edition 45, 7239-7243.PMID: 17009353
- Ahmad G., Dickerson MB, Church BC, Ye Cai, Jones SE, King SJ, Summers CJ, Kröger N., Naik RR. & Sandhage KH. (2006) Rapid Room-Temperature Formation of Crystalline Calcium Molybdate Phosphor Microparticles via Peptide-Induced Precipitation. Advanced Materials 18, 1759-1763.
- Sandhage, KH., Allan, S.M., Dickerson M.B., Gaddis, C.S., Shian, S., Weatherspoon, M.R., Cia Ye, Ahmad, G., Haluska M.S., Snyder R.L., Unocic R.R., Zalor, F.M., Zhang Y., Rapp, R.A., Hildebrand M. & Palenik B.P. (2005). Merging biological self-assembly with synthetic chemical tailoring: The potential for 3-D genetically engineered micro/nano-devices (3-D GEMS). International Journal of Applied Ceramic Technology, 2(4) 314-326.
- Ahmad, G., Sachdeva, S., Malhotra, P., Mukherjee, P. & Chauhan, V.S. (2004) Comparison of immunogenicities of recombinant Plasmodium vivax Merozoite Surface Protein 1 19 and 42 Kilo Dalton fragments expressed in Escherichia coli. Infection and Immunity 72:5775-5782. PMID:15385477
- Ahmad, G., Saifullah, M.K., & Nizami, W. A (2004) Partial purification and characterization of Gigantocotyle explanatum somatic antigens. Journal of Helminthology 78: 95-99. PMID: 15153279.
- Maestre, A., Sunil, S., Ahmad ,G., Mohmmed, A. , Marcela, A., Mauricio, C., Silvia, B. Chauhan V.S. & Malhotra, P. (2004) Plasmodium vivax: Inter-allelic recombination in the merozoite surface protein 1 among Indian and Colombian isolates. Malaria Journal (3). (1) 4. PMID: 15003129
- Malhotra, M. , Ahmad, G. , Sachdeva, S., Bhardwaj, A., Lalitha, P.V., Rao, P.P. & Chauhan, V.S (2003). Immunogenicity of E. coli expressed Plasmodium falciparum and Plasmodium vivax MSP-1 42 and MSP-1 19 proteins with different adjuvants. Vaccine 21:3513-3514.
- Ahmad, G., Nizami, W. A. Saifullah , M. K. (2001) Analysis of potential antigens of protoscoleces isolated from pulmonary and hepatic hydatid cysts of Bubalus bubalis. Comparative Immunology Microbiology and Infectious Diseases 24 (2): 91-101. PMID: 11247049
- Saifullah , M. K., Ahmad, G., Nizami, W. A. (2000) Effect of parasitism on the biomolecules of Gyralus convexusculus hepatopancreas. Journal of Veterinary Parasitology 14: 21-26.
- Saifullah , M. K., Ahmad, G., Nizami, W. A. and Abidi, S. M. .A.(2000) Partial purification and characterization of Gastrothylax crumenifer somatic antigens. Veterinary Parasitology 89:23-29 PMID:10729642.
- Saifullah , M. K., Ahmad, G. and Nizami, W. A. (2000) Analysis of excretory -secretory and somatic antigens of Gastrothylax crumenifer (Trematoda: Digenea). Journal of Helminthology 74: 271-276. PMID: 11203057
- Ahmad G. and Nizami, W. A. (1998) Partial purification of protoscolex antigens and their possible role in the immunodiagnosis of echinococcosis. Parasitologia Hungarica 31: 39-45.
- Ahmad, G. and Nizami, W. A. (1998) Coproantigens: Early detection and suitability of an immunodiagnostic method for echinococcosis in dogs. Veterinary Parasitology 77: 237-244. PMID: 9763314
- Sandhage, KH., Allan, S.M., Dickerson M.B., Ernst, E.M. Gaddis, C.S., Shian, S., Weatherspoon, M.R., Ahmad, G., Cia Ye, Haluska M.S., Snyder R.L., Unocic R.R. & Zalor, F.M.(2007) Inorganic preforms of biological origin:Shape-Preserving reactive conversion of biosilica microshellls (Diatoms), In: Handbook of Biomineralization, Biomimetic and Bio-inspired Chemistry Vol.2 Pages:235-253. (P. Behrens, E. Bauerlein, eds.), Wiley-VCH, Weinheim, (Germany).
- Nizami, W.A. and Ahmad, G. (1995) Cadmium pollution and prevalence of infectious diseases in the Indian perspective. In: "Toxicity and Monitoring of Xenobiotics" pp. 67-78. Prakash, R. and Sood, P. eds. Venus Publishing House, New Delhi, (INDIA).